Methods and compositions for regulating nuclear trafficking...

Details Methods and compositions for regulating nuclear trafficking... Methods and compositions for regulating nuclear trafficking...

A - Human Necessities

61

K

A61K 38/00 (2006.01) C07K 14/47 (2006.01) C07K 14/50 (2006.01)

Patent

CA 2298066

Methods and compositions are provided to regulate the trafficking of nuclear proteins, including the high molecular weight forms of FGF-2, to the nucleus. A nuclear trafficking component, which is approximately 29 kD, is identified as binding to and regulating nuclear localization of FGF-2. Inhibitors of the binding of 29 kD and FGF-2 are provided.

L'invention concerne des procédés et des compositions permettant de réguler le transport des protéines nucléaires vers le noyau, notamment le transport des formes de FGH2 à poids moléculaire élevé. Un constituant de transport nucléaire, de l'ordre de 29kD, est identifié comme se liant à FGF2 et comme régulant la localisation nucléaire de FGF2. L'invention concerne également des inhibiteurs de la liaison du constituant de 29kD et de FGF2.

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