Use of selective ep4 receptor agonists for the treatment of...

Details Use of selective ep4 receptor agonists for the treatment of... Use of selective ep4 receptor agonists for the treatment of...

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/41 (2006.01)

Patent

CA 2479222

The present invention is directed to methods for treating liver failure, loss of patency of the ductus arteriosus, glaucoma or ocular hypertension, comprising administering to the patient in need thereof a therapeutically effective amount of a selective EP4 receptor agonist of formulae (I) or (II) wherein the variables A, B, Q, =U, and R2 for Formula (I); and the variables Ar, =M, =N, R, W, and Z for Formula (II) are as defined in the specification.

L'invention concerne des méthodes de traitement de l'insuffisance cardiaque, de la perte de la perméabilité du canal artériel, du glaucome ou de l'hypertension oculaire. Ces méthodes consistent à administrer à un patient ayant besoin de ce traitement une dose thérapeutiquement efficace d'un agoniste du récepteur EP¿4? sélectif représenté par la formule (I) ou (II), dans laquelle les variables A, B, Q, =U, et R?2¿ pour la formule (I); et les variables Ar, =M, =N, R, W, et Z pour la formule (II), sont telles que définies dans le descriptif.

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