Methods and compositions using optically pure (+)-zileuton

Details Methods and compositions using optically pure (+)-zileuton Methods and compositions using optically pure (+)-zileuton

A - Human Necessities

61

K

A61K 31/38 (2006.01)

Patent

CA 2161777

Methods and compositions are disclosed utilizing optically pure (+)- zileuton for the treatment of asthma, rheumatoid arthritis and ulcerative colitis in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of zileuton. (+)-Zileuton is an inhibitor of 5-lipoxygenase and is therefore useful in the treatment of other conditions related to elevated leukotriene levels. (+)-Zileuton is also an antioxidant and is therefore useful in treating or preventing artherosclerosis.

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