Disorders of vasoregulation and methods of diagnosing them

Details Disorders of vasoregulation and methods of diagnosing them Disorders of vasoregulation and methods of diagnosing them

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2703264

The present invention relates to various in vitro methods of diagnosing a vasoregulation disorder or a predisposition thereto in a subject being suspected of having developed or of having a predisposition to develop a vasoregulation disorder or in a subject being suspected of being a carrier for a vasoregulation disorder, wherein the vasoregulation disorder is selected from hypertension, migraine, pre-eclampsia and recurrent pregnancy loss. Moreover, the present invention also relates to methods for identifying compounds capable of modulating coagulation factor XII activity, suitable as medicaments or as lead compound for a medicament for the treatment and/or prevention of a vasoregulation disorder. Furthermore, the present invention relates to gene therapy methods and to a kit for diagnosing a vasoregulation disorder.

La présente invention porte sur divers procédés in vitrode diagnostic d'un trouble de la vasorégulation ou d'une prédisposition à celui-ci chez un sujet soupçonné d'avoir développé ou d'avoir une prédisposition à développer un trouble de la vasorégulation ou chez un sujet soupçonné d'être un porteur pour un trouble de la vasorégulation, le trouble de la vasorégulation étant choisi parmi l'hypertension, la migraine, la pré-éclampsie et la fausse couche récurrente. De plus, la présente invention porte également sur des procédés d'identification de composés capables de moduler l'activité du facteur XII de la coagulation, appropriés comme médicaments ou comme composé tête de série pour un médicament pour le traitement et/ou la prévention d'un trouble de la vasorégulation. De plus, la présente invention porte sur des procédés de thérapie génique et sur un coffret pour le diagnostic d'un trouble de la vasorégulation.

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