C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/04 (2006.01) A61K 31/437 (2006.01) A61K 31/472 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2431471
A compound of the formula (I) wherein A, R1~, R2~ and X have the meanings defined in the specification, process of manufacturing such as compound and a pharmaceutical composition with HDAC inhibitor activity and anti-cell proliferation activity containing such a compound.
La présente invention concerne un composé de formule (I), dans laquelle A, R1, R2 et X ont les significations énoncées dans la description, un procédé pour produire un tel composé, ainsi qu'une composition pharmaceutique comprenant ledit composé et présentant une activité d'inhibition de HDAC et une activité d'inhibition de prolifération cellulaire.
Georges Guy
Grossmann Adelbert
Mundigl Olaf
Sattelkau Tim
von Der Saal Wolfgang
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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