3 dimensional cell system (organoids) and associated protocols

Details 3 dimensional cell system (organoids) and associated protocols 3 dimensional cell system (organoids) and associated protocols

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12Q 1/02 (2006.01)

Patent

CA 2375788

Novel 3-dimensional in vitro models of mammalian tissues are provided. In a preferred embodiment, the models simulate behavior of human cancerous tissues at various stages of a solid tumour progression or the cell senescence, apoptosis or tissue regeneration in normal or cancerous human cells. The models are particularly useful for screening and testing of anticancerous drugs and assessing their toxicity for both the tumour and the surrounding tissue. Novel cellular automaton models for analysis and simulation of 3- dimensional cell organoids have also been developed. These models are useful for studying intercellular communication and predicting effects of gap junction channels modulating drugs.

La présente invention concerne des modèles in vitro en trois dimensions de tissus de mammifères. Dans un mode préféré de l'invention, les modèles simulent le comportement de tissus humains cancéreux à divers stades de la progression d'une tumeur solide ou la sénescence des cellules, l'apoptose ou la régénération de tissus dans des cellules humaines cancéreuses ou normales. Ces modèles conviennent particulièrement pour la recherche et les essais de médicaments anticancéreux et pour l'évaluation de leur toxicité tant pour la tumeur que pour les tissus environnants. Des nouveaux modèles automates cellulaires destinés à l'analyse et la simulation d'organoïdes cellulaires en trois dimensions ont également été développés. Ces modèles sont utiles pour étudier la communication intercellulaire et les effets prévus de médicaments régulateurs des canaux de jonction lacunaire.

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