A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/426 (2006.01)
Patent
CA 2732863
The present invention relates to a pharmaceutical composition for preventing and treating osteoporosis, comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4- yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3- thiazol-4-yl)phenoxy]pentoxy}benzamidine, or salts thereof, and alendronic acid or a salt thereof. As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of N-hydroxy-4-{5-[4- (5-isopropyl-2-methyl-l,3-thiazol-4- yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4- yl)phenoxy]pentoxy}-benzamidine, or salts thereof and alendronic acid or a salt thereof exhibits excellent inhibitory effect on osteoclast differentiation, as compared to each individual treatment, thereby being useful for the prevention or treatment of osteoporosis.
La présente invention concerne une composition pharmaceutique pour prévenir et traiter l'ostéoporose, qui comprend du N-hydroxy-4-{5-[4-(5-isopropyl-2-méthyl-1,3-thiazol-4-yl)phénoxy]pentoxy}benzamidine, du 4-{5-[4-(5-isopropyl-2-méthyl-1,3-thiazol-4-yl)phénoxy]pentoxy}benzamidine, ou des sels de ceux-ci, et de l'acide alendronique ou un sel de celui-ci. En tant que composition prophylactique ou thérapeutique pour l'ostéoporose, un traitement combiné à base de N-hydroxy-4-{5-[4-(5-isopropyl-2-méthyl-1,3-thiazol-4-yl)phénoxy]pentoxy}benzamidine, de 4-{5-[4-(5-isopropyl-2-méthyl-1,3-thiazol-4-yl)phénoxy]pentoxy}-benzamidine, ou de sels de ceux-ci et d'acide alendronique ou d'un sel de celui-ci permet d'assurer un excellent effet inhibiteur sur la différenciation des ostéoclastes, par comparaison avec chaque traitement individuel, ce qui s'avère être utile pour la prévention ou le traitement de l'ostéoporose.
Chung Duk Kyun
Hwang Yun Ha
Lee Jin Soo
Park Jae Hoon
Ryu Jei Man
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Dong Wha Pharmaceutical Co. Ltd.
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