Integrin receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/02 (2006.01) A61K 31/44 (2006.01) A61K 45/06 (2006.01) C07D 213/73 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2338878

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha.v.beta.3, .alpha.v.beta.5 and/or .alpha.v$(b)6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, and tumor growth and metastasis.

Cette invention se rapporte à des composés et à des dérivés de ceux-ci, à leur synthèse et à leur utilisation comme antagonistes de récepteurs d'intégrine. Les composés faisant l'objet de cette invention sont plus particulièrement des antagonistes des récepteurs d'intégrine .alpha.v.beta.3, .alpha.v.beta.5 et/ou .alpha.v.beta.6 et ils servent à inhiber la résorption osseuse, à traiter et à prévenir l'ostéoporose et à inhiber la resténose vasculaire, la rétinopathie diabétique, la dégénération maculaire, l'angiogenèse, l'athérosclérose, les inflammatons, l'arthrite inflammatoire, les maladies virales et la croissance des tumeurs et les métastases.

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