Substituted cyclohexane derivatives, processes for their...

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C - Chemistry, Metallurgy

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C07C 69/00 (2006.01) A61K 31/00 (2006.01) C07C 69/757 (2006.01) C07C 271/64 (2006.01) C07C 323/62 (2006.01) C07D 207/16 (2006.01) C07D 209/42 (2006.01) C07D 213/55 (2006.01) C07D 213/79 (2006.01) C07D 215/48 (2006.01) C07D 233/60 (2006.01) C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 239/26 (2006.01) C07D 285/06 (2006.01) C07D 307/85 (2006.01) C07D 333/00 (2006.01) C07D 333/16 (2006.01) C07D 333/24 (2006.01) C07D 333/28 (2006.01) C07D 333/38 (2006.01) C07D 333/68 (2006.01) C07D 493/10 (2006.01) C07D 495

Patent

CA 2105709

Substituted cyclohexane derivatives, processes for their preparation, and the use of the compounds for treating diseases Cyclohexane derivatives of the formula I (See Formula I) in which R1 is CN, COOH, C1-C4-alkanoyl, SO3-C1-C4-alkyl, SO3H or SO2NR8R9; R2 is C1-C10-alkyl(R11)n, O-C1-C10- alkyl(R11)n, C2-C10-alkenyl(R11)n, O-C3-C10-alkenyl(R11)n, C2- C10-alkynyl(R11)n, O-C3-C10-alkynyl(R11)n, S-C1-C10-alkyl(R11)n, S-C3-C10-alkenyl(R11)n, S-C3-C10-alkynyl(R11)n, NH-C1-C10- alkyl(R11)n, NH-C3-C10-alkenyl(R11)n, or NH-C3-C10- alkynyl(R11)n, where R11 is unsubstituted or substituted in each case by R12; R3 is unsubstituted or substituted indolyl, imidazolyl, benzimidazolyl, quinolyl or tetrazolyl; R11 and R13 are identical or different and are alkyl with 1 to 10 carbon atoms, cycloalkyl with 3-8 ring carbon atoms, or unsubsituted or substituted phenyl, naphthyl, phenanthryl, thienyl, furyl or coumarinyl; R4. R5 and R6 are identical or different and are H, OH, a protected OH group, F, Cl or Br; R7 is C1-C4-alkyl, phenyl or benzyl; R8 and R9 are identical or different and are H, C1-C4-alkyl, C1-C4-alkanoyl, or unsubstituted or substituted phenyl; R12 is substituted or unsubstituted phenyl, naphthyl, phenanthryl, thienyl, furyl or coumarinyl; X is (CH2)m, -CH=CH-, -CSC-, -CH2-O-CH2-, -CH2-S-CH2- or -CH2-N(R8)-CH2-; Y is (CH2)m, O, S or NR8; Z is (CH2)m, S, O, S-C1-C10-alkyl, O-C1-C10-alkyl, CH=CH, CH=CF, CH=CCl, CH=CBr, CH2-CO, CH2-CHF, CH2-CHCl, CH2 -CHBr, CH2-CHI, C3-C10-cycloalkylene, C3-C10-cycloalkenylene, COOR7, C.ident.C, CH=C(C1-C4-alkyl), CH=C(CN), CH=C(NR8R9), CH=C(C1-C4-alkanoyl), CH=C(R13), NR8, or C3-C10-cycloalkylene or C3-C10-cycloalkenylene in which 1 to 3 ring carbon atoms are replaced by sulfur or oxygen atoms, and when Y is oxygen, -C(O)-Z-R3 can together be an amino-acid residue and protected derivatives thereof; n is zero, 1 or 2; m is zero, 1, 2, 3 or 4; or a physiologically tolerated salt thereof, and processes for the preparation of these compounds are described. The compounds have valuable pharmacological properties and can therefore be used as pharmaceuticals.

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