The use of kauranes compounds in the manufacture of medicament

Details The use of kauranes compounds in the manufacture of medicament The use of kauranes compounds in the manufacture of medicament

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 31/00 (2006.01) A61P 7/00 (2006.01) A61P 9/04 (2006.01) A61P 9/06 (2006.01) A61P 9/08 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2606472

This invention relates to the use of kauranes compounds having the structure of formula (I) in the manufacture of a medicament for treating and preventing the diseases such as coronary heart disease, cerebral apoplexy, cerebral ischemia and rhythm disturbance etc. The present compounds also have obvious protective effect against cerebral infarction and cerebral injure from ischemia, In which: R1 is H, hydroxy or alkoxy; R2 is carboxy, carboxylate group, acyl halide, aldehyde group, hydroxymethyl, ester group which can be hydrolyzed to carboxy, amide, acyl or ether group; R3, R4, R5, R6, R8 each independently are H, hydroxy, hydroxymethyl, ester group which can be hydrolyzed to hydroxymethyl, or alkoxymethyl; R7 is methyl, hydroxymethyl, ester group which can be hydrolyzed to hydroxymethyl, or alkoxymethyl; R9 is methylene or oxygen atom.

L'invention concerne l'utilisation de composés de kaurane de formule (I) dans l'élaboration d'un médicament destiné à traiter et à prévenir certaines maladies, telles que la coronaropathie, l'apoplexie, l'ischémie cérébrale et les troubles du rythme cardiaque etc. Les composés de cette invention présentent également un effet protecteur évident contre l'infarctus cérébral et les accidents cérébraux résultant d'une ischémie. Dans ladite formule, R?1¿ représente hydroxy ou alkoxy, R?2¿ représente carboxy, un groupe carboxylate, un halogénure d'acyle, un groupe aldéhyde, un hydroxyméthyle, un groupe ester qui peuvent être hydrolysés en groupe carboxy, amide, acyle ou éther, R?3¿, R?4¿, R?5¿, R?6¿ représentent respectivement un groupe hydrogène, hydroxy, hydroxyméthyle, ester qui peuvent être hydrolysés en hydroxyméthyle ou alkoxyméthyle, R?7¿ représente un groupe méthyle, hydroxyméthyle, ester qui peuvent être hydrolysés en hydroxyméthyle ou alkoxyméthyle, R?9¿ représente un atome de méthylène ou d'oxygène.

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