C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61K 31/255 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61K 31/66 (2006.01) C07C 309/71 (2006.01) C07C 309/72 (2006.01) C07C 309/73 (2006.01) C07C 311/14 (2006.01) C07C 311/29 (2006.01) C07C 317/44 (2006.01) C07C 323/56 (2006.01) C07C 323/60 (2006.01) C07D 233/56 (2006.01) C07D 233/84 (2006.01) C07D 261/10 (2006.01) C07D 261/16 (2006.01) C07D 333/34 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07F 9/53
Patent
CA 2260190
There are provided compounds of formula (I), wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
L'invention concerne des composés de formule (I), dans laquelle R?1¿, R?2¿, R?3¿, Y, n et B ont la signification mentionnée dans la description. Ces composés sont utiles comme inhibiteurs compétitifs des protéases de type trypsine, telles que la thrombine, notamment pour le traitement des états où une inhibition de la thrombine est nécessaire (thrombose par exemple), ou comme anticoagulants.
Astra Aktiebolag
Fetherstonhaugh & Co.
LandOfFree
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