C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 335/04 (2006.01) C07C 259/06 (2006.01) C07C 275/64 (2006.01) C07C 311/19 (2006.01) C07C 327/38 (2006.01)
Patent
CA 2502527
The present invention relates to novel n-hydroxythiourea, urea and amide compounds as a potent vanilloid receptor antagonist and the pharmaceutical compositions comprising the same. The inventive compound can be useful for analgesics to prevent, alleviate or treat pain diseases or inflammatory disease comprising pain, acute pain, chronic pain, neuropathic pain, post- operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease and urgent urinary incontinence.
L'invention concerne de nouveaux composés de n-hydroxythiourée, d'urée et amides en tant qu'antagoniste puissant du récepteur de vanilloïde et les compositions pharmaceutiques les renfermant. Le composé selon l'invention peut servir d'analgésique pour empêcher, soulager ou traiter des états douloureux ou inflammatoires tels que douleur, douleur aiguë, chronique, neuropathique, postopératoire ou migraineuse, arthralgie, neuropathies, lésions nerveuses, neuropathie diabétique, neurodégénérescence, affection cutanée névrotique, accident vasculaire cérébral, hypersensibilité de la vessie, syndrome du côlon irritable, trouble respiratoire, par exemple l'asthme ou une maladie pulmonaire obstructive chronique, irritation de la peau, de l'oeil ou de la muqueuse, hyperthermie, ulcère gastro-duodénal, affection intestinale inflammatoire, maladie inflammatoire ou incontinence urinaire sévère.
Digital Biotech Co. Ltd.
Marks & Clerk
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