Bispecific antibodies for retargeting anticancer cytotoxic...

Details Bispecific antibodies for retargeting anticancer cytotoxic... Bispecific antibodies for retargeting anticancer cytotoxic...

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/20 (2006.01)

Patent

CA 2330189

A bispecific antibody has binding specificity for a marker common to all prostate cells on one arm of the antibody, and binding specificity for T cell marker CD3 on the other antibody arm. The combined specificities bring together a tumor cell and a T effector cell, whose specificity is reprogrammed to kill the tumor cell. In vitro studies showed that the bispecific antibody achieves a much greater level of cytotoxicity than either individual antibody alone.

La présente invention concerne un anticorps bivalent présentant une spécificité de liaison pour un marqueur commun à toutes les cellules de la prostate sur un bras, et une spécificité de liaison pour le marqueur de cellule T CD3 sur l'autre bras. Ces spécificités combinées permettent de réunir une cellule tumorale et une cellule T effectrice, dont la spécificité est reprogrammée pour tuer la cellule tumorale. Des études in vitro ont démontré que l'anticorps bivalent de l'invention présente un niveau de cytotoxicité beaucoup plus élevé que les anticorps individuels utilisés seuls.

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