Process for preparing pyridazinone compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 237/14 (2006.01)

Patent

CA 2563225

The present invention provides a process for the preparation 6-[3- (hetero)aryloxy-2-~fluoro-benzyl] -2H-pyridazin-3-one compounds of formula VIII wherein R2 is an optionally substituted aryl or an optionally substituted heteroaryl, X is C1-6 alkyl, halogen, or a function group readily derived therefrom and R5 is H, C02R5a or formula C; R5a is hydrogen or C1-6 alkyl; R4c is hydrogen or C1-6 alkyl.

La présente invention a trait à un procédé pour la préparation de composés à base de 6-[3-(hétéro)aryloxy-2--fluoro-benzyl] -2H-pyridazin-3-one de formule VIII, dans laquelle : R?2¿ est un aryle éventuellement substitué ou un hétéroaryle éventuellement substitué ; X est un alkyle en C¿1?-C¿6?, halogène, ou un groupe fonctionnel dérivé de celui-ci ; et R?5¿ est H, CO¿2?R?5a¿ ou la formule C ; R?5a¿ est hydrogène ou alkyle en C¿1?-C¿6 ?; R?4c¿ est hydrogène ou alkyle en C¿1?-C¿6?.

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