Formulation for stabilizing enzymatic activity and...

Details Formulation for stabilizing enzymatic activity and... Formulation for stabilizing enzymatic activity and...

C - Chemistry, Metallurgy

12

N

C12N 9/96 (2006.01) A01N 1/02 (2006.01) A61K 35/14 (2006.01) C12N 9/12 (2006.01) C12Q 1/50 (2006.01) G01N 33/573 (2006.01) G01N 33/70 (2006.01)

Patent

CA 2106167

TITLE FORMULATION FOR STABILIZING ENZYMATIC ACTIVITY AND IMMUNOREACTIVITY OF CREATINE KINASE AND CREATINE KINASE ISOENZYMES ABSTRACT OF THE DISCLOSURE A formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes comprising animal serum, creatine kinase and/or creatine kinase isoenzymes, an effective amount of a buffer having a pKa in the range of 6.2-7.6 to maintain pH of the formulation at 6.7?0.1, an effective amount of a non-thiol antioxidant to prevent oxidation of creatine kinase or creatine kinase isoenzyme thiol groups, an effective amount of a non- reducing polyol to stabilize immunoreactivity of creatine kinase or creatine kinase isoenzymes, and an effective amount of an antimicrobial to prevent microbial growth is provided.

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