C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 35/76 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 1/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2441397
The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating gastrointestinal diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
La présente invention concerne des protéines humaines sécrétées et des molécules isolées d'acides nucléiques codant pour lesdits polypeptides, qui conviennent bien pour le diagnostic et le traitement de maladies et troubles gastro-intestinaux et autres pathologies connexes. Cette invention porte également sur des anticorps qui se lient à ces polypeptides. Elle englobe également des vecteurs, cellules hôtes ainsi que des méthodes recombinantes et synthétiques permettant de produire lesdits polynucléotides, polypeptides, et/ou anticorps. L'invention concerne en outre des procédés de criblage permettant d'identifier des agonistes et des antagonistes desdits polynucléotides et polypeptides. Sont enfin décrites des méthodes et des compositions pouvant inhiber ou favoriser la production et la fonction des polypeptides selon l'invention.
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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