Derivatives of amide analogs of certain methano bridged...

Details Derivatives of amide analogs of certain methano bridged... Derivatives of amide analogs of certain methano bridged...

C - Chemistry, Metallurgy

07

D

C07D 471/18 (2006.01) A61K 31/435 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 491/22 (2006.01) C07D 495/22 (2006.01) C07D 497/22 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2070573

This invention relates to novel amide derivatives of certain hexahydro-8-hydroxy-2,6-methano-2H-quinolizine-type compounds. to the intermediates and processes for their preparation, to their ability to induce a blockage of 5HT3 receptors, and to their end-use application in the treat- ment of chemotherapeutically-induced nausea and vomiting, as anti-anxiety agents, in the symptomatic treatment of pain associated with migraine, as anti-arrhythmic agents, in the treatment of cognitive disorders, in treating hallucinatory endogenous psychoses of the type manifested in patients suffering from schizophrenia, and mania, in the treatment of glaucoma, far stimulating gastric motility, to combat drug abuse, to treat sleep apnea and to treat irritable bowel syndrome.

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