C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/04 (2006.01)
Patent
CA 2760524
The invention describes novel virus-like particles for use as vaccines, diagnostic tools and R&D tools based on recombinant DNA and cell cultivation techniques for production. The recombinant virus-like particles of the invention are assembled by polypeptide chains that incorporate several, in particular two or more, different epitopes which are selected either (a) from different viral strains of the same virus and/or (b) from different serotypes of the same virus and/or (c) from different viral strains specific for different hosts. These epitopes are then displayed on the particle surface.
L'invention concerne de nouvelles particules de type virus destinées à être utilisées comme vaccins, outils de diagnostic et outils de R&D sur la base d'ADN recombinant et de techniques de culture des cellules pour la production. Les particules recombinantes de type virus selon l'invention sont assemblées par des chaînes polypeptides qui incorporent plusieurs, en particulier deux ou plus de deux, épitopes différents qui sont sélectionnés (a) parmi différentes souches virales du même virus et/ou (b) parmi différents sérotypes du même virus et/ou (c) parmi différentes souches virales spécifiques pour différents hôtes. Ces épitopes sont ensuite exposés sur la surface des particules.
John Corinne
Schaub Christian
Wellnitz Sabine
Fetherstonhaugh & Co.
Redbiotec Ag
LandOfFree
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