C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) A61K 31/5513 (2006.01) A61K 31/5517 (2006.01) A61P 25/28 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 223/00 (2006.01) C07D 235/00 (2006.01) C07D 241/00 (2006.01) C07D 243/00 (2006.01) C07D 243/24 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01) C07D 471/06 (2006.01) C07D 471/08 (2006.01) C07D 487/06 (2006.01)
Patent
CA 2395862
This invention relates to novel carbocycles and heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.
La présente invention concerne de nouveaux carbocycles et hétérocycles présentant des propriétés médicamenteuses et ayant une influence biologique, leurs compositions pharmaceutiques et leurs méthodes d'utilisation. Ces nouveaux composés inhibent le traitement de la protéine précurseur amyloïde et, plus spécifiquement, la production de peptide A.beta., agissant ainsi pour prévenir la formation de dépôts neurologiques de protéine amyloïde. Plus particulièrement, la présente invention concerne le traitement de troubles neurologiques liés à la production de .beta.-amyloïde, tels que la maladie d'Alhzeimer et le syndrome de Down.
Deng Wei
Liu Hong
Maduskuie Thomas P.
Olson Richard E.
Tebben Andrew J.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
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