Cripto blocking antibodies and uses thereof

Details Cripto blocking antibodies and uses thereof Cripto blocking antibodies and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) C12N 5/09 (2010.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2715570

The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signalling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signalling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications.

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