Process for the preparation of thalidomide

Details Process for the preparation of thalidomide Process for the preparation of thalidomide

C - Chemistry, Metallurgy

07

D

C07D 211/88 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/17 (2006.01) A61K 31/197 (2006.01) A61K 31/27 (2006.01) A61K 31/45 (2006.01) C07C 211/27 (2006.01) C07C 229/08 (2006.01) C07C 229/22 (2006.01) C07C 237/22 (2006.01) C07C 275/28 (2006.01)

Patent

CA 2626178

The present invention relates to compounds which are useful for reducing levels of TNF.alpha. in a mammal. Examples of compounds include those of formula: Image wherein, for example, R7 is a cyclic alkyl, a substituted phenyl, etc ...; n is 1 and R12 is an alkoxy, a disubstituted amino, etc ...; those of formula: Image wherein, for example, Z is Image or R4 NH- n is 1, 2 or 3; R1 is a divalent residue of 3,4-pyridine, pyrrolidine, etc ...; R2 is -CO- or -SO2-; R3 is a substituted phenyl, pyridyl, etc ...; and R4 is alanyl, argynyl, etc.

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