A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/08 (2006.01) A61K 31/4164 (2006.01) A61K 45/00 (2006.01) A61K 47/10 (2006.01) A61P 17/00 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2478074
It is intended to provide substances having an effect of promoting the percutaneous absorption of an antifungal agent, etc. to thereby potentiate its efficacy on an intractable skin disease such as athlete~s foot and a high safety to the skin having elevated sensitivity to irritation due to the disease. It is found out that coenzyme Q, the high safety of which has been ascertained in oral administration, is highly safe to the skin and has an effect of promoting the percutaneous absorption of an antifungal agent. Based on these results, it is possible to provide compositions with the combined use of coenzyme Q and an antifungal agent efficacious on athlete~s foot which can be hardly cured completely.
L'invention concerne des substances favorisant l'absorption percutanée d'un agent antifongique, par exemple, afin de potentialiser son efficacité sur une maladie rebelle de la peau, telle que l'irritation due à un effort sportif, et de limiter les risques d'application sur une peau dont la sensibilité et l'irritation sont accrues sous l'effet de cette maladie. On a découvert que le coenzyme Q, dont on a établi l'absence de risques par administration orale, ne présente aucun danger pour la peau et exerce un effet de promotion de l'absorption percutanée d'un agent antifongique. Il est possible, en fonction de ces résultats, de préparer des compositions associant le coenzyme Q et un agent antifongique efficace contre l'irritation du pied suivant un effort sportif, qu'il est difficile de guérir complètement.
Fujii Kenji
Hidaka Takayoshi
Hosoe Kazunori
Kawabe Taizo
Kaneka Corporation
Riches Mckenzie & Herbert Llp
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