Imidazoline derivatives having cb1-antagonistic activity

C - Chemistry – Metallurgy – 07 – D

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C07D 233/00 (2006.01)

Patent

CA 2553372

The present invention relates to 1,2,4-tri-substituted imidazoline derivatives, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said imidazoline derivatives, to methods for the preparation of these intermediates, to pharmaceutical compositions containing one or more of these imidazoline derivatives as active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.

La présente invention concerne des dérivés d'imidazoline 1,2,4- tri-substitués, des méthodes d'obtention de ces composés, des nouveaux intermédiaires utiles pour la synthèse desdits dérivés d'imidazoline, des méthodes d'obtention d ces intermédiaires, des compositions pharmaceutiques contenant un ou plusieurs de ces dérivés d'imidazoline comme principe actif ainsi que l'utilisation de ces compositions pharmaceutiques pour le traitement de troubles psychiatriques et neurologiques. Ces composés sont représentés par la formule générale (I)dans laquelle les symboles ont la définition qui leur est donnée dans le descriptif de l'invention.

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