Combined use of dipeptidyl peptidase 4 inhibitor and sweetener

Details Combined use of dipeptidyl peptidase 4 inhibitor and sweetener Combined use of dipeptidyl peptidase 4 inhibitor and sweetener

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/047 (2006.01) A61K 31/40 (2006.01) A61K 31/496 (2006.01) A61K 31/54 (2006.01) A61K 31/7004 (2006.01) A61K 31/702 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2682736

It is intended to provide a novel therapeutic or preventive method which exhibits an excellent anti-obesity effect (an effect of reducing body fat and/or an effect of reducing body fat) and a pharmaceutical composition, and use thereof. The pharmaceutical composition comprising a dipeptidyl peptidase IV inhibitor compound and a sweetener having an action of promoting GLP-1 secretion in combination, and the use thereof in the production of a pharmaceutical. Further, the therapeutic or preventive method for obesity, characterized by administering an effective amount of (a) a dipeptidyl peptidase IV inhibitor compound and (b) a sweetener having an action of promoting GLP-1 secretion to a patient with obesity symptoms.

L'invention concerne la fourniture d'un nouveau procédé thérapeutique ou de prévention qui présente un excellent effet anti-obésité (un effet de réduction de tissu adipeux), et d'une composition pharmaceutique, et leur utilisation. L'invention concerne la composition pharmaceutique comprenant un composé inhibiteur de dipeptidylpeptidase IV et un adoucisseur ayant une action de promotion de sécrétion de GLP-1 en combinaison, et son utilisation dans la production d'un produit pharmaceutique. De plus, l'invention concerne le procédé thérapeutique contre l'obésité ou de prévention de l'obésité, caractérisé par l'administration d'une quantité efficace (a) d'un composé inhibiteur de dipeptidylpeptidase IV, et (b) d'un adoucisseur ayant une action de promotion de sécrétion de GLP-1, à un patient souffrant des symptômes d'obésité.

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