Polymer microgel beads and preparative method thereof

C - Chemistry – Metallurgy – 08 – K

Patent

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Details

C08K 3/10 (2006.01) A61K 41/00 (2006.01) A61K 47/02 (2006.01) A61N 2/10 (2006.01) C08F 2/32 (2006.01) C08F 2/44 (2006.01) C08F 20/06 (2006.01)

Patent

CA 2724177

The present invention relates to polymer microgel beads having a polymeric matrix with nanomagnetic particles dispersed substantially uniformly therethrough, wherein a steric stabiliser is associated with the particles, the steric stabiliser being a polymeric material that (i) forms at least part of the polymeric matrix of the beads, and (ii) comprises a steric stabilising polymeric segment and an anchoring polymeric segment, wherein the steric stabilising polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the nanomagnetic particles and secures the stabiliser to the particles.

La présente invention concerne des billes polymères à base de microgel qui ont une matrice polymère dans laquelle des particules nanomagnétiques sont dispersées de manière sensiblement uniforme. Selon l'invention, un agent stabilisant stérique est associé aux particules. L'agent stabilisant stérique est une matière polymère (i) qui forme au moins partie de la matrice polymère des billes, et (ii) qui comprend un segment polymère stabilisant stérique et un segment polymère d'ancrage, le segment polymère stabilisant stérique étant différent du segment polymère d'ancrage, et le segment polymère d'ancrage présentant une affinité vis-à-vis de la surface des particules nanomagnétiques et fixant l'agent stabilisant aux particules.

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