C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/140
C12P 19/18 (2006.01) C12P 19/04 (2006.01)
Patent
CA 2015675
BIO-ORGANIC SYNTHESIS OF DIMERIC Lex (DIFUCOSYL Y2; III3FucV3FucnLc6Cer) AND ANALOGUES THEREOF ABSTRACT OF THE INVENTION A process for preparing difucosyl Y2 antigen (dimeric Lex), said process comprising: (1) preparing a lactonorhexaosylceramide backbone or a lactonorhexa- osylsaccharide backbone linked to a carrier molecule; and (2) enzymatically fucosylating said backbone at the III3 and V3 positions through an .alpha.1->3 linkage. A process for preparing Ley antigen analogues, said process comprising: (1) preparing a lactonorhexaosyl- ceramide backbone or a lactonorhexaosylsaccharide backbone linked to a carrier molecule; (2) enzyma- tically fucosylating said backbone at the terminal .beta.-Gal through an .alpha.1->2 linkage; and (3) enzymatically fucosylating said backbone at one or more positions through an .alpha.1->3 linkage, provided that steps (2) and (3) can be conducted simultaneously or in any order. A process for preparing a fucosylated lactonorhexaosyl- ceramide, lactonorhexaosylsaccharide linked to a carrier molecule or higher analogues thereof, said process comprising: (1) preparing a lactonorhexaosyl- ceramide backbone, a lactonorhexaosylsaccharide backbone linked to a carrier molecule or backbones of higher analogues thereof; and (2) enzymatically fucosylating one or more residues of said backbone.
Clausen Henrik
Hakomori Sen-Itiroh
Nudelman Edward
Sadozai Khalid
Stroud Mark R.
Biomembrane Institute (the)
Clausen Henrik
G. Ronald Bell & Associates
Hakomori Sen-Itiroh
Nudelman Edward
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