Fibrinogen-coated microspheres

Details Fibrinogen-coated microspheres Fibrinogen-coated microspheres

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 38/36 (2006.01) A61K 38/38 (2006.01)

Patent

CA 2294494

The invention provides compositions comprising microspheres of fibrinogen- coated cross-linked albumin microspheres having a size range of primarily from about 100 to about 5000 nanometers diameter, wherein the composition is substantially free microspheres and microsphere aggregates having a diameter of more than 10 micrometers. At least a portion of the fibrinogen on the surface of the microspheres is covalently attached. The particles of the invention are useful for reducing bleeding time when administered to a human or other animal.

L'invention concerne des compositions refermant des microsphères d'albumine réticulées enrobées de fibrinogène dont le diamètre est principalement de l'ordre de 100 à 5000 nm environ. Ladite composition est sensiblement constituée de microsphères libres et d'agrégats de microsphères ayant un diamètre supérieur à 10 µm. Une portion au moins du fibrinogène se trouvant sur la surface des microsphères est fixée par covalence. Les particules de l'invention sont utiles pour réduire le temps de saignement lorsqu'elles sont administrées à un humain ou à un animal.

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