Ternary ligand complexes useful as radiopharmaceuticals

A - Human Necessities – 61 – K

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A61K 51/00 (2006.01) A61K 51/04 (2006.01) C07D 213/77 (2006.01) C07D 213/82 (2006.01) C07F 9/50 (2006.01) C07F 13/00 (2006.01)

Patent

CA 2287974

The present invention provides novel radiopharmaceuticals useful for imaging the heart, brain, lungs, liver or kidneys, kits useful for preparing the radiopharmaceuticals, and methods of imaging the heart, brain, lungs, liver or kidneys in a patient in need of such imaging. The radiopharmaceuticals are comprised of technetium or rhenium radionuclide complexes of a ternary ligand system: one hydrazido or diazenido ligand, one aminoalcohol ligand, and one pi- acid ligand selected from phosphines, arsines, and imine nitrogen-containing heterocyles. The radiopharmaceuticals have the formula ML1L2L3, wherein the variables are as defined herein.

L'invention concerne de nouveaux produits radiopharmaceutiques utiles pour réaliser l'imagerie du coeur, du cerveau, des poumons, du foie ou des reins, des trousses servant à préparer ces produits radiopharmaceutiques, ainsi que des procédés d'imagerie du coeur, du cerveau, des poumons, du foie ou des reins. Ces produits radiopharmaceutiques sont composés de complexes de radionucléides de technétium ou de rhénium d'un système ternaire de ligands: un ligand hydrazido ou diazénido, un ligand d'aminoalcool et un ligand de pi-acide sélectionné dans des phosphines, des arsines et des composés hétérocycliques d'imine contenant azote. Ces produits radiopharmaceutiques sont représentés par la formule: ML?1¿L?2¿L?3¿, dont les variables sont définies dans le descriptif.

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