Bone-related sulfatase-like protein and process for its...

Details Bone-related sulfatase-like protein and process for its... Bone-related sulfatase-like protein and process for its...

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C12N 9/16 (2006.01) C12N 15/62 (2006.01) C12P 21/08 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2104995

Abstract of the Disclosure A bone-related protein named OSF-8 which is obtained from bone tissue of a mammal including mouse or human, and a process for its production. This protein is a novel naturally occurring mammal protein which belongs to a group of sulfatases. OSF-8 degrades the sulfate groups of the sugar chains of proteoglycan, which makes up the cartilage matrix, during the replacement of cartilage into bone tissue at the stage of osteogenesis. OSF-8 can be used as an agent for treating bone metabolic diseases, and its high organ specificity for bones enables its use as a diagnostic reagent for bone metabolic diseases.

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