Extracellular/epidermal growth factor like protein

Details Extracellular/epidermal growth factor like protein Extracellular/epidermal growth factor like protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/485 (2006.01) C07K 16/22 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/86 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2286351

The present invention discloses extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptide and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

La présente invention concerne des polypeptides de facteur de croissance extracellulaire/épidermique, ainsi que des polynucléotides codant de tels polypeptides. L'invention concerne également un procédé de production de tels polypeptides faisant appel à des techniques de recombinaison et les utilisations thérapeutiques de ces polypeptides, lesquelles comprennent l'induction de la synthèse d'ADN, la stimulation de la cicatrisation de blessures, le traitement de troubles neurologiques, le traitement de troubles oculaires, le traitement de troubles rénaux et hépatiques et la stimulation de l'embryogenèse et de l'angiogenèse. Sont également décrits des antagonistes s'opposant à de tels polypeptides et leur utilisation comme agents thérapeutiques pour traiter la néoplasie. L'invention concerne en outre des dosages diagnostiques permettant de détecter des taux modifiés de polypeptides selon l'invention et des mutations dans les séquences nucléotidiques qui codent ces polypeptides.

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