Glycolipids, their preparation and use

C - Chemistry – Metallurgy – 12 – P

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C12P 19/26 (2006.01) C07H 15/10 (2006.01) C12P 19/18 (2006.01)

Patent

CA 2133103

2133103 9320226 PCTABS00027 A process for preparing a glycolipid of formula (I): [(sac)m+n]-O-CH2-CHX-CH(OQ)-Y wherein Q is H or a blocking group; X is N3 or NH2; Y is a lipid residue; each sac is a saccharide; and m and n are each integers; comprises reacting a corresponding glycolipid of formula (II): (sac)n-O-CH2-CHX-CH(OQ)-Y with the corresponding saccharide (sac)m or a reactive derivative thereof, in the presence of an enzyme that catalyses the reaction. Compounds of formulae (I) and (II) are suitable for elaboration to a variety of saccharide ceramides.

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