Stabilized antithrombin iii preparation

Details Stabilized antithrombin iii preparation Stabilized antithrombin iii preparation

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 38/57 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) C12N 7/04 (2006.01) A61K 47/02 (2006.01)

Patent

CA 2291851

A stabilized antithrombin III preparation is described which is protected against a loss of action during pasteurization by the addition of stabilizers which consist of one or more saccharides in a mixture with more than 0.5 mol/l of one or more amino acids from the group consisting of arginine, lysine, histidine, phenylalanine, tryptophan, tyrosine, aspartic acid and its salts or glutamic acid and its salts, it also being possible to additionally add glycine or glutamine to each of these amino acids.

Divulgation d'une préparation d'antithrombine III stabilisée, protégée contre une perte d'efficacité pendant la pasteurisation par l'addition de stabilisants constitués d'un ou de plusieurs saccharides mélangés avec plus de 0,5 mole/L d'un ou plusieurs acides aminés du groupe constitué par l'arginine, la lysine, l'histidine, la phénylalanine, le tryptophane, la tyrosine, l'acide aspartique et ses sels ou l'acide glutamique et ses sels. Il est aussi possible d'ajouter en plus de la glycine ou de la glutamine à chacun de ces acides aminés.

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