C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) A61P 13/12 (2006.01) A61P 43/00 (2006.01) C07K 14/62 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 37/00 (2006.01)
Patent
CA 2509356
It is intended to provide a novel glucose and/or fructose transporter relating to renal diabetes, its gene, mutants thereof and utilization of the same. The above-described glucose and/or fructose transporter and its gene are a glucose and/or fructose transporter and its gene relating to renal diabetes and the protein and the gene respectively comprise a novel protein which is highly expressed in the kidney and largely contributes to the glucose reabsorption in the kidney and its gene. Moreover, mutants of the protein and the gene as described above and an antibody binding specifically to the protein are included. Furthermore, a nonhuman model animal lacking the above-described gene on chromosome, a method of screening a preventive/a remedy for renal diabetes, a method of diagnosing a glucose and/or fructose transporter function or a renal disease by using the gene or the antibody as described above, and a method of controlling the transporter function of tissue cells by transferring the above gene into the tissue cells are included.
L'invention concerne un nouveau transporteur de glucose et/ou fructose relatifs aux diabètes rénaux, son gène, des mutants de celui-ci et son utilisation, ledit transporteur de glucose et/ou fructose et son gène étant un transporteur et un gène associés aux diabètes rénaux. La protéine et le gène comprennent respectivement une nouvelle protéine à expression élevée dans le rein qui contribue largement à la réabsorption du glucose dans ledit rein et son gène. L'invention concerne également des mutants de la protéine et de son gène et un anticorps se liant spécifiquement à ladite protéine. L'invention concerne, en outre, un animal modèle non humain manquant du gène précité sur un chromosome, un procédé de criblage d'une substance préventive/d'un médicament pour les diabètes rénaux, un procédé de diagnostic de fonction de transporteur de glucose et/ou fructose ou d'une maladie rénale par utilisation du gène ou de l'anticorps précités, et un procédé permettant de réguler la fonction de transporteur de cellules tissulaires par transfert du gène précité dans des cellules tissulaires.
Inui Ken-Ichi
Masuda Satohiro
Japan Science And Technology Agency
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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