Compositions and methods for determining and predicting...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/04 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2577141

The invention provides genetic means, including compositions (e.g., kits) and methods, to predict the efficacy of a treatment in depression and anxiety and to predict a patient's response to a particular a specific medication or treatment. The invention provides methods for diagnosing the presence of a psychiatric disorder or determining the outcome of a treatment for a psychiatric disorder. The invention provides methods for methods for diagnosing the presence of a psychiatric disorder in an individual by determining what corticotropin-releasing hormone receptor 1 (CRHR1) protein or transcript isoforms are expressed in an individual. The invention provides methods for diagnosing the presence of a psychiatric disorder in an individual by determining what protein or transcript isoforms are expressed in an individual wherein the protein is involved in the hypothalamic-pituitary- adrenal (HPA) axis pathway.

L'invention concerne des moyens génétiques, notamment des compositions (par exemple, des kits) et des procédés permettant de prévoir l'efficacité d'un traitement dans le cas de dépression et d'anxiété et de prévoir la réponse d'un patient à un médicament ou traitement spécifique. L'invention concerne également des procédés permettant de diagnostiquer la présence d'un trouble psychiatrique ou permettant de déterminer le résultat d'un traitement d'un trouble psychiatrique. L'invention concerne également des procédés permettant de diagnostiquer la présence d'un trouble psychiatrique chez un individu par détermination de quelles protéine ou isoformes de transcription du récepteur 1 de l'hormone de libération de la corticotropine (CRHR1) sont exprimées chez l'individu. L'invention concerne enfin des procédés permettant de diagnostiquer la présence d'un trouble psychiatrique chez un individu par détermination de quelles protéine ou isoformes de transcriptase sont exprimées chez l'individu, la protéine étant impliquée dans la voie axiale hypothalamique-pituitaire-surrénal (HPA).

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