C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/65 (2006.01) A61K 31/44 (2006.01) A61K 31/443 (2006.01) A61K 31/4433 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4706 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61P 1/00 (2006.01) A61P 1/18 (2006.01) A61P 9/00 (2006.01) A61P 9/06 (2006.01) A61P 13/00 (2006.01) A61P 13/10 (2006.01) A61P 15/00 (2006.01) A61P 19/02 (2006.01) A61P 21/02 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/06 (2006
Patent
CA 2761639
The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S)blockers such as NaV1.3 and NaV1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved.
La présente invention porte sur des dérivés de carboxamide substitués par aryle de formule (I) ou un sel pharmaceutiquement acceptable de ceux-ci, qui ont des activités de blocage de canaux calciques de type T ou de canaux sodiques dépendants d'un potentiel d'action comme les inhibiteurs sensibles à la tétrodotoxine (TTX-S) tels que NaV1.3 et NaV1.7, et qui sont utiles dans le traitement ou la prévention de troubles et maladies dans lesquels les canaux calciques de type T ou les canaux sodiques dépendants d'un potentiel d'action sont impliqués. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés et sur l'utilisation de ces composés et compositions dans la prévention ou le traitement des maladies dans lesquelles les canaux calciques de type T ou les canaux sodiques dépendants d'un potentiel d'action sont impliqués.
Arano Yoshimasa
Inoue Tadashi
Morita Mikio
Shimada Kaoru
Watanabe Shuzo
Raqualia Pharma Inc.
Torys Llp
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