C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/02 (2006.01)
Patent
CA 2584815
Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. -20 ~C). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 106 PFU/mL to 1012 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10.
L'invention concerne des virus à enveloppe (par exemple des virus de la maladie de Newcastle (NDV)) formulés pour un stockage dans des conditions de froid modéré (par exemple 20°C). La formulation de l'invention est une solution aqueuse contenant le virus enveloppé à un concentration comprise entre 106 PFU/mL et 1012 PFU/mL; et un saccharide non réducteur (par exemple, un sucrose). Lorsque le saccharide non réducteur est un disaccharide, il est présent dans la solution à une concentration comprise entre 5 % (p/v) et 50 % (p/v), et lorsque c'est un monosaccharide, il est présent dans la solution à une concentration comprise entre 2,5 % (p/v) et 25 % (p/v). La solution présente une variation osmotique supérieure ou égale à 250 mOs, et présente un pH compris entre 5 et 10.
Chen Tzer-Fen
Jang Jouhn-Wern
Miller Jeffrey A.
Gowling Lafleur Henderson Llp
Wellstat Biologics Corporation
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