Rna interference

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/04 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2509636

The present invention relates to RNA interference and methods for selecting interfering RNAs. The present invention also relates to modified interfering RNAs. The present invention also relates to methods of reducing the level of a specific mRNA in a cell, methods for reducing the level of a specific protein in a cell, and methods of regulating gene expression. The present invention also relates to methods of screening libraries for an interfering RNA of interest and methods of screening libraries based on a gene function.

L'invention concerne l'interférence ARN et des procédés de sélection des ARN interférants. Elle porte également sur des ARN interférants modifiés ainsi que sur des procédés de réduction du niveau d'un ARNm spécifique dans une cellule, sur des procédés de réduction du niveau d'une protéine spécifique dans une cellule et sur des procédés de régulation de l'expression génique. L'invention se rapporte encore à des procédés de criblage de banques à la recherche d'un ARN d'intérêt et à des procédés de criblage de banques selon une fonction de gène.

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