Novel substituted heteroaromatic compounds as inhibitors of...

Details Novel substituted heteroaromatic compounds as inhibitors of... Novel substituted heteroaromatic compounds as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 235/18 (2006.01) A61K 31/4164 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 471/04 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2720654

Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desat-urase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

Les composés hétéroaromatiques substitués de formule structurale I sont des inhibiteurs de la stéaroyl-coenzyme A delta-9 désaturase. Les composés de la présente invention sont utiles pour la prévention et le traitement daffections liées à des anomalies de synthèse et de métabolisme des lipides, y compris des maladies cardiovasculaires, telles que lathérosclérose; lobésité; le diabète de type 2; la résistance à linsuline; lhyperglycémie; le syndrome métabolique; des maladies neurologiques; le cancer; et la stéatose hépatique. Formule (I).

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