C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 311/00 (2006.01) C07D 491/18 (2006.01) C07K 14/31 (2006.01) C30B 29/58 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2380335
The present invention provides the atomic coordinates derived from high resolution x-ray diffraction of the cocrystal complex comprising mupirocin with its target enzyme, isoleucyl-tRNA synthetase form Staphylococcus aureus, and the cognate tRNAile from Escherichia coli. The present invention further provides methods of using the atomic coordinates to identify and design new agents which modulate protein synthesis as well as the agents themselves.
La présente invention concerne les coordonnées atomiques obtenues par cristallographie par rayons X à haute résolution du complexe de co-cristal comprenant de la mupirocine et son enzyme cible, la synthétase ARNt-isoleucyle issue du Staphylococcus aureus, et le ARNt?ile¿ parent issu de Escherichia coli. La présente invention concerne également des procédés d'utilisation des cordonnées atomiques pour identifier et concevoir de nouveaux médicaments qui modulent la synthèse des protéines ainsi que les agents eux-mêmes.
Silvian Laura F.
Steitz Thomas A.
Wang Jimin
Gowling Lafleur Henderson Llp
Yale University
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