C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 48/00 (2006.01) C07K 1/113 (2006.01) C07K 14/245 (2006.01) C12N 9/04 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2374021
The present invention provides a method for regulating the conformation of proteins using molecular chaperones. The chaperones of the present invention are applicable to a variety of protein conformational problems including misfolding and aggregation. A molecular chaperone system of the present invention includes the DnaK system and ClpB which provides a particularly effective tool for regulating protein conformation. A further subject of the present invention is a cochaperone ClpS.
Cette invention concerne une méthode de régulation de protéines au moyen de chaperons moléculaires. Dans le cadre de la présente invention, les chaperons peuvent s'utiliser pour divers problèmes de conformation, y compris mauvais repliement et agrégation. Selon la présente invention, un système de chaperons moléculaires comprend le système Dnak et ClpB qui constitue un outil particulièrement efficace pour la régulation de la conformation des protéines. L'invention porte également sur un nouveau co-chaperon ClpS.
Bukau Bernd
Goloubinoff Pierre
Borden Ladner Gervais Llp
Roche Diagnostics Gmbh
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