Use of (halobenzyloxy) benzylamino-propanamides for the...

A - Human Necessities – 61 – K

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A61K 31/165 (2006.01) A61K 31/00 (2006.01) A61K 45/06 (2006.01) A61P 1/00 (2006.01) A61P 3/00 (2006.01) A61P 5/00 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) A61P 17/00 (2006.01) A61P 25/02 (2006.01) A61P 25/06 (2006.01) A61P 25/08 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2577408

The invention relates to the use of selected (R) -2~- [(halobenzyloxy)benzylamino]-propanamides and the pharmaceutically acceptable salts thereof for the manufacture of medicament, that are selectively active assodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, pain, migraine, periferal diseases, cardiovascular diseases, inflammatory processes affecting all body systems, disorders affecting skin and related tissues, disorders of the respiratory system, disorders of the immune and endocrinological systems, gastrointestinal, urogenital, metabolic and seizure disorders, where the above mechanisms have been described as playing a pathological role.

L'invention concerne l'utilisation de (R)-2-[(halobenzyloxy)benzylamino]-propanamides et de leurs sels pharmaceutiquement acceptables pour la fabrication d'un médicament, ces composés étant des modulateurs des canaux sodiques et/ou calciques sélectivement actifs et trouvant donc une utilité dans la prévention, l'atténuation et le traitement d'une multitude de pathologies telles que la douleur, la migraine, les maladies périphériques, les maladies cardiovasculaires, les processus inflammatoires affectant tous les systèmes du corps, les troubles affectant la peau et les tissus associés, les troubles du système respiratoire, les troubles des systèmes immunitaire et endocrinologique, ainsi que les troubles gastro-intestinaux, urogénitaux, métaboliques et épileptiques, les mécanismes susmentionnés ayant été décrits comme jouant un rôle pathologique.

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