Inhibitors of cyclic guanosine 3', 5'-monophosphates...

Details Inhibitors of cyclic guanosine 3', 5'-monophosphates... Inhibitors of cyclic guanosine 3', 5'-monophosphates...

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/4985 (2006.01) A61P 9/00 (2006.01) C07D 495/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2423280

Compounds answering to the general structural formula (I) Image have been found to be potent and selective inhibitors of cyclic guanosine 3',5'- monophosphates specific phosphodiesterase (cGMP-specific-PDE), in particular PDE5. Such compounds are useful in the treatment of a number of conditions in animals, including cardiovascular disorders and erectile disfunction.

L'invention porte sur des composés de formule structurelle générale (I) et leur et celle de leurs sels et solvates comme agents thérapeutiques.

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