C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/22 (2006.01) A61K 31/409 (2006.01) A61K 31/437 (2006.01) A61K 41/00 (2006.01) A61K 49/06 (2006.01) A61P 35/00 (2006.01) C07D 487/22 (2006.01)
Patent
CA 2490692
Provided herein are tetrapyrrole compounds containing a fluorinated substituent for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferative tissue are provided. In another embodiment, compounds that absorb light at a wavelength of from about 700 to about 850 nm are provided. In a further embodiment, compounds that are detectable by magnetic resonance imaging are provided.
L'invention concerne des composés de détection, de diagnostic et de traitement de tissus cibles ou de compositions cibles, tels que des tissus hyperprolifératifs, par ex des tumeurs, au moyen de procédés photodynamiques. L'invention concerne notamment des composés photosensibilisants s'agglomérant dans des tissus hyperprolifératifs. Dans un autre mode de réalisation, l'invention concerne des composés absorbant de la lumière à une longueur d'onde de 700 à 850 nm. Dans un mode de réalisation ultérieur, l'invention concerne des composés pouvant être détectés par imagerie par résonance magnétique.
Dougherty Thomas J.
Pandey Ravindra K.
Potter William R.
Gowling Lafleur Henderson Llp
Health Research Inc.
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