A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 47/48 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2462425
The present invention provides a composition comprising a 5'-OR, 3'- TEG cholesteryl synthetic sequence wherein the sequence is SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, and a pharmaceutically acceptable carrier. The present invention also provides methods of using of this composition in preparation of medicaments, and methods of using this composition for induction of a response in a cell, including but not limited to inhibition of cellular proliferation, induction of cell cycle arrest, induction of caspase activation, cleavage of poly(ADP-ribose) polymerase, induction of apoptosis or modulation of extracellular matrix-cell interactions, or combinations thereof, in cancer cells and/or synovial cells.
La présente invention concerne une composition comprenant une séquence synthétique de 5'-OR, 3'- TEG cholestéryle dont la séquence correspond aux SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, et un excipient pharmaceutiquement acceptable. L'invention se rapporte également à des procédés d'utilisation de ladite composition dans la préparation de médicaments et à des procédés d'utilisation de ladite composition pour induire une réponse cellulaire, y compris mais de manière non limitative, l'inhibition de la prolifération cellulaire, l'induction de l'interruption du cycle cellulaire, l'induction de l'activation de la caspase, le clivage de la poly(ADP-ribose) polymérase, l'induction de l'apoptose ou la modulation des interactions entre matrice extracellulaire et cellule, ou des combinaisons des réponses cellulaires précitées, dans des cellules cancéreuses et/ou synoviales.
Filion Mario C.
Herrera-Gayol Andrea Cristina
Phillips Nigel C.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Bioniche Life Sciences Inc.
Herrera-Gayol Andrea Cristina
LandOfFree
Therapeutically useful triethyleneglycol cholesteryl... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Therapeutically useful triethyleneglycol cholesteryl..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutically useful triethyleneglycol cholesteryl... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1900216