Synthesis of inhibitors of 11beta-hydroxysteroid...

Details Synthesis of inhibitors of 11beta-hydroxysteroid... Synthesis of inhibitors of 11beta-hydroxysteroid...

C - Chemistry, Metallurgy

07

D

C07D 265/10 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 417/10 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2697168

Disclosed are syntheses of 11 .beta.-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra- ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).

L'invention porte sur des synthèse d'inhibiteurs de la 11ß-HSDl et d'intermédiaires correspondants qui sont prometteurs pour le traitement d'une diversité d'états maladifs comprenant le diabète, le syndrome métabolique, l'obésité, l'intolérance au glucose, la résistance à l'insuline, l'hyperglycémie, l'hypertension, les troubles cardiovasculaires liés à l'hypertension, l'hyperlipidémie, les effets glucocorticoïdes délétères sur une fonction neuronale (par exemple, déficience cognitive, démence et/ou dépression), une pression intraoculaire élevée, diverses formes de maladie osseuse (par exemple, ostéoporose), la tuberculose, la lèpre (maladie de Hansen), le psoriasis, et la cicatrisation défectueuse (par exemple, chez des patients qui présentent une tolérance au glucose défectueuse et/ou un diabète de type 2).

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