Process for the preparation of c-4 deacetyltaxanes

Details Process for the preparation of c-4 deacetyltaxanes Process for the preparation of c-4 deacetyltaxanes

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) C12N 9/00 (2006.01) C12P 15/00 (2006.01) C12P 17/02 (2006.01)

Patent

CA 2340471

A process useful for the preparation of intermediates in synthesis or semi- synthesis of paclitaxel analogs wherein a starting taxane such as 10- deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom to provide 4-deacetyltaxanes, such as 4,10- dideacetylbaccatin III.

L'invention porte sur un procédé de préparation d'intermédiaires de synthèse ou de demi synthèse d'analogues de paclitaxel consistant à déacétyler un taxane tel que le 10-déacétylbaccatine III en position C-4 à l'aide de micro-organismes ou d'une enzyme en dérivant pour obtenir des 4-déacétyltaxanes tels que les 4,10-didéacétylbaccatine III.

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