Process for the production of hetero-bispecific antibodies

Details Process for the production of hetero-bispecific antibodies Process for the production of hetero-bispecific antibodies

C - Chemistry, Metallurgy

12

P

167/139

C12P 21/00 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2012631

For the production of hetero-bispecific monoclonal antibodies at least the genes for the light chain and for the variable part of the heavy chain are isolated from a hybridoma cell line which secretes an antibody with a desired specificity and they are inserted into a eukaryotic plasmid vector which contains a marker capable of selection together with a strong promoter, this expression vector is transfected into a hybridoma cell line which secretes antibodies with a second desired specificity, the cell line is cultured, the antibodies are obtained and the bispecific antibody is isolated.

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