A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/085 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2603805
The present composition combines an RNAIII-inhibiting peptide (RIP) with an antimicrobial peptide, such as a cathelicidin, that is capable of binding and neutralizing lipidic and polyanionic components of bacterial cell envelope. In another embodiment, the RIP is combined with an antibiotic, with or without an antimicrobial peptide. The present composition is advantageously used in a method of treatment of bacterial sepsis.
La présente invention concerne une composition qui combine un peptide inhibiteur de l'ARNIII (RIP) à un peptide antimicrobien, tel qu'une cathélicidine, qui est capable de se lier à des composants lipidiques et polyanioniques d'enveloppe cellulaire bactérienne et de les neutraliser. Dans un autre mode de réalisation, le peptide RIP est combiné à un antibiotique, avec ou sans peptide antimicrobien. Cette invention présente l'avantage d'être utilisée dans une méthode de traitement de sepsis bactérien.
Balaban Naomi
Blake Cassels & Graydon Llp
LandOfFree
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