Recombinant human mannan-binding proteins and process for...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 39/00 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2318851

The present invention is directed to recombinant Human Mannan-Binding Proteins (rhMBP) having physiological activities which are substantially identical to those offered by Human Mannan-Binding Proteins (hMBP). The invention further provides a production system for homogenously producing rhMBP having the specific peaks at the molecular weight of 1,0001,300 kDa determined by absorbance (280nm) in gel-filtration chromatography.

Un système de production destiné à une production homogène de protéines fixatrices de mannane humaines recombinantes (rhMBP) est comparable, au point de vue activité physiologique, à des protéines fixatrices de mannane humaines (hMBP), en particulier, à celles présentant un pic spécifique pour une masse moléculaire comprise entre 1000 et 1300 kDa dans l'absorbance (280 nm) en chromatographie par filtration sur gel.

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