Use of mcp-1 for inducing ripening of the cervix

A - Human Necessities – 61 – K

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A61K 38/19 (2006.01) C07K 14/52 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2186370

Monocyte chemotactic peptide-1 or a functional derivative thereof is useful in inducing cervical ripening, for example for. (A) induction of labour at term, (B) induction of labour in connection with a pathological pregnancy, (C) induction of labour in connection with intrauterine fetal death, (D) induction of abortion, (E) induction of preterm labour, (F) induction of cervical ripening of a non-pregnant female or pregnant female to assist for surgical or diagnostic procedure, and (G) induction of cervical ripening for female to be treated by in vitro fertilisation.

Le peptide-1 chimiotactique à monocyte ou un dérivé fonctionnel de celui-ci est utile pour induire la maturation du col de l'utérus, par exemple dans les cas suivants: (A) provocation de l'accouchement à terme; (B) provocation de l'accouchement en cas de grossesse pathologique; (C) provocation de l'accouchement par suite de mort intra-utérine du fétus; (D) provocation de l'avortement; (E) provocation d'un accouchement avant terme; (F) induction de la maturation du col de l'utérus d'une femelle non enceinte ou enceinte afin d'aider à une procédure chirurgicale ou diagnostique, et (G) induction de la maturation du col de l'utérus chez une femelle devant subir une fertilisation in vitro.

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